血清C-反应蛋白和唾液酸联合测定在新生儿细菌感染性疾病中的意义

Simultaneous Determination of Serum Levels of C-Reactive Protein and Sialic Acid in the Diagnosis and Treatment of Neonatal Bacterial Infection

目的 探讨血清Ｃ－反应蛋白（ＣＲＰ）和唾液酸（ＳＡ）联合测定在新生儿早期细菌感染诊断和疗效观察中的意义。方法同时测定５２例起病在１周内的细菌感染新生儿血清ＣＲＰ和ＳＡ水平。结果 ＣＲＰ在起病２４ ｈ内即增加到（６８．３±３２．８）ｍｇ／Ｌ，与正常对照组[（０．７８±０．２５）ｍｇ／Ｌ］相比差异具有显著性（Ｐ ＜ ０．０１），当炎症得到一定控制后则明显下降（Ｐ＜ ０．０１）。ＳＡ在起病２４ ｈ内逐渐增加，至１～３ ｄ和４～７ ｄ时分别升至（１．８８±０．８５），（２．９５±０．８７）ｍｍｏｌ／Ｌ，与对照组[（０．９１±０．４０）ｍｍｏｌ／Ｌ］比较差异具有显著性意义（Ｐ ＜ ０．０１），当感染得到完全控制时可降至正常对照水平。结论 血清ＣＲＰ和ＳＡ的联合测定，有助于提高新生儿早期细菌感染性疾病的诊疗水平。

Objective To study the clinical significance of simultaneous determination serum contents of C-reactive protein(CRP) and sialic acid(SA) in the diagnosis and treatment of neonatal bacterial infection. Methods Serum levels of CRP and SA were simultaneously determined in the same sample in 52 neonates(ranging from day 1 to 1 week of life) with bacterial inf ection. Results The serum CRP level [(68.3±32.8)mg/L] significantly increased within 24 hours of infection compared with that in the non-i nfection neonates [(0.78±0.25)mg/L](P < 0.01).When the infection was pa rtially or completely controlled the serum CRP level decreased significantly(P< 0.01). The serum SA content within 24 hours of infection was increased, but it w as not s ignificantly different from that in the normal cases [(0.91±0.40)mmol/L]. It was gradually elevated and became significant at day 1～3 and day 4～7 of infection [(1.88±0.85) and(2.95±0.87)mmol/L,respectively](P < 0.01).Only when the infection was completely controlled did the serum SA content in infection neonates reduce to normal. Conclusions The combined assay of serum CRP and SA contents is helpful in making an earlier diagnosis and proper treatme nt for neonatal bacterial infection.