摘要
目的观察系膜增殖性肾小球肾炎(MsPGN)患儿肾活检标本α-平滑肌肌动蛋白(α-SMA)的表达与临床表现的关系。方法 应用免疫组化技术,结合计算机图像分析系统检测33例不同血脂和血压水平的MsPGN患儿肾小球内α-SMA的含量改变。结果 MsPGN伴高脂血症和高血压的患儿肾小球内α-SMA含量高于正常血脂和正常血压组(P < 0.05)。结论 高脂血症和高血压可促进MsPGN患儿肾小球系膜细胞发生表型改变。
Objective To study the relationship between α-smooth muscle actin(α-SMA) and clinical symptoms(hypertension and hyperlipoproteinemia ) in children with mesangial proliferative glomerulonephritis(MsPGN). Methods Expression of α-SMA was detected using immunohistochemistry and computer image evaluation in 33 children with MsPGN. Results The expression of α-SMA was higher in MsPGN children with hypertension and/or hyperlipoproteinemia than that in MsPGN children without hypertension and/or hyperlipoproteinemia(P < 0.05). Conclusions Expression of α-SMA by mesangial cells appears to be activated by hypertension and hyperlipoproteinemia in children with MsPGN.
出处
《中国当代儿科杂志》
CAS
CSCD
2002年第2期106-108,共3页
Chinese Journal of Contemporary Pediatrics