摘要
目的 :探讨狼疮性肾炎尿毒症患者的临床特点和预后影响的因素。方法 :通过随访方式追踪患者的临床表现 ,实验室及治疗的资料 ,采用COX回归模型 ,进行单因素及多因素分析。结果 :10 2例患者中 ,有 37例死亡 (占36 .3% ) ,主要死因是发生感染 ,占 40 .5 4% ;多因素分析显示血尿酸、内生肌酐清除率、肾萎缩与否、BUN和血白蛋白水平对预后有显著影响 ,且为独立因素 ,而临床分型、性别、SLEDAI并不是影响预后的独立因素。结论 :高水平的尿酸和BUN为独立危险因素 ,而肾无萎缩、血白蛋白和内生肌酐清除率的维持有利于肾功能的改善。
Objective:To explore the clinical feature and influential factors of the prognosis of lupus nephritis uremia.Methods:Collected the clinical data of lupus nephritis uremia,and analyzed them with COX regression.Results:In 102 cases,37 patients died,infection was the major cause.And uric acid,endogenous creatinine clearance,the size of kidney,the blood urea nitrogen and albumin had significant influence on the prognosis,while the clinical type,sex,SLEDAI hadn't.Conclusion:High concentration of uric acid and blood urea nitrogen were the independent hazard factors,while the maintenance of endogenous creatinine clearance,albumin concentration and normal size of kidney were helpful to improve the renal function.
出处
《中国中西医结合肾病杂志》
2002年第5期271-274,共4页
Chinese Journal of Integrated Traditional and Western Nephrology
