异氟醚吸入麻醉时药代动力学模型的建立及临床测评

The establishment and clinical evaluation of pharmacokinetic animal model of isoflurance inhaling anesthesia

目的 确定异氟醚 (Iso)吸入麻醉时浓度 -时间数学模型 ,并评价其可信性。方法 20例ASA1～2级全麻病人 ,气管插管后持续以1L/minO2 载入挥发罐1.5%Iso靶浓度 ,麻醉气体监测仪测定病人呼气末Iso浓度 (FETIso)。其中A组10例以FETIso与时间作图并建立数学模型 ;B组10例根据数学模型计算理论值 ,并与实际值进行执行误差(PE %)分析。 结果 1.本实验条件下数学模型为FETIso(t)/104=43.4136e0.1042t-27.2380e-11.7658t;2.理论值执行误差除1min为 +30.3%外 ,其他各点均在±10 %以内。结论 该数学模型能较为正确地预测FETIso ;而挥发罐所给定的Iso靶浓度在实验观察结束时尚未能达到。

Objective To set up the concentration-time mathematical model in isoflurance inhaling anesthesia, and to evaluate the reliability. Method 20 general anesthesia patients of ASA1～2 were continually given 1.5% Iso volatilizal jar target concentration with 1L/min O2 after tracheal cannula, estimated FETIso by anesthesia gas monitor. Group A set up mathematical model with FETIso and time. Group B calculated theory value according to established model, analyse PE% compared with actual value. Results Mathematical model is FETIso(t)/104= 43.4136e0.1042t-27.2380e-11.7658t. PE% is +30.3% in 1 min, in other spot are less than ±10%. Conclusion Mathematical model could accuratedly predict FETIso, Iso target concentration have not been obtained at the end of experiment.