拉米夫定联用活血疏肝汤治疗老年慢性乙型肝炎的序贯研究

Sequential Analysis of Therapeutic Effect of Lamivudine Tablet and Promoting Blood Circulation and Soothing the liver soup on Aged Patients with Chronic Hepatitis B

目的 :观察拉米夫定联用活血疏肝汤治疗老年慢性乙型肝炎的疗效。方法 :采用序贯试验的方法先后观察 44对老年慢性乙型肝炎患者 ,每对患者随机分入试验组 (拉米夫定联用活血疏肝汤 )和对照组 (单用拉米夫定 )。治疗前后分别检测乙肝五项、HBVDNA和肝功能。结果 :第 31对患者触及U线 ,拉米夫定联用活血疏肝汤疗效优于单用拉米夫定。试验组HBeAg的阴转率为 84 1% ,优于对照组6 3 6 % ,p <0 0 5。结论

Objective: To observe the therapeutic effects of lamivudine tablet and promoting blood circulation and soothing the liver soup on aged patients with chronic hepatitis B.Methods:Sequential analysis was used in the study.Forty four pairs of aged patients with chronic hepatitis B were permitted in the study who were randomly divided into trail group and control group.Patients in trial group were treated with lamivudine tablet and promoting blood circulation and soothing the liver soup and the others received lamivudine monotherapy.The outcome measures used were hepatitis B〃e〃antigen(HBeAg)seroconversion rates and HBV DNA and the liver function test.Results:The thirty first patient touched the U line.The end of treatment efficacy of this combination scheme is superior to that of lamivudine monotherapy.The HBeAg seroconversion rate of the trial group is 84.1%,compare to 63.6% of those in control group(p<0.05).Conclusion:The therapeutic effects of lamivudine tablet and the promoting blood circulation and soothing the liver soup on aged patients with chronic hepatitis B is superior to that of the lamivudine monotherapy.