左旋氨氯地平治疗轻中度高血压疗效及不良反应的临床研究

Clinic Study of the Efficacy and Adverse Reactions Levamlodipine Besylate in Treatment of Hypertension

目的:为评价左旋氨氯地平降压疗效及不良反应,并与氨氯地平相比较。方法:采用随机分组平行对照方法,将120例轻、中度高血压患者分成左旋氨氯地平组(60例),口服2.5～5mg·d^(-1)和氨氯地平组(60例),口服5～10mg·d^(-1)。观察5周。每周一次上午延迟1～4小时用药并测诊室谷值坐位血压、心率、观察不良反应。结果:5周未左旋氨氯地平与氨氯地平组治疗有效反应率分别为86.7％和83.3％,每组治疗前后比较差异非常显著(P<0.01)。组间比无显著性差异(P>0.05)。左旋氨氯地平组不良反应发生率6.7％,氨氯地平组为16.7％(P>0.05),但试验组不良反应程度更轻微。结论:左旋氨氯地平与氨氯地平治疗高血压同样有效,不良反应可能更小。

Objective: To evaluate the efficacy and adverse reactions of levamlodipine besylate tablet in treatment of hypertension and compare it with amlodipine besylate. Methods: 120 patients with mild or moderate hypertension were randomly divided to receive 2.5-5mg · d-1 levamlodipine besylate tablet or amlodipine besylate tablet 5- 10mg · d-1 for 5 weeks . Weekly the patients were taken trough seat DBF,heart rate and receiven drugs late 1-4 hours . All patients were observed adverse reactions . Results: No significant differences between groups were observed in total effective reaction rate (P> 0.05). Levamlodipine group have milder adverse reactions than amlodipine. Conclusion: levamlodipine is an effective agent for treatment of hypertension and milder side effect .