全国细菌药敏试验的室间质量评价

The External Quality Assessment of Antibiotic Susceptibility Test in China

目的:了解全国大中型医院细菌药敏试验(AST)状况,提高检测水平和质量。方法:定期向全国各参加评价实验室发放冻干标本,要求在规定时间内报告可疑感染的病原菌及其药敏结果,对回报结果给予数据统计、分析和评价。结果:2000年全国489个细菌室对常见耐药菌的检测正确率分别为:超广谱β-内酰胺酶63％(ESBLs);苯唑西林敏感金黄色葡萄球菌(MSSA)74％;苯唑西林耐药凝固酶阴性葡萄球菌(MRSCoN)48％;对青霉素不敏感肺炎链球菌7％;氨基糖苷类高水平耐药肠球菌95％;产β-内酰胺酶流感嗜血杆菌正确率35％。结论:通过细菌药敏试验的室间质量评价反映出我国的细菌耐药性检测水平急待提高。

Objective: To investigate and improve the quality of antibiotic susceptibility test (AST) in China. Methods: The dried - free samples were distributed to all laboratories participating the external quality assessment (EQA)scheme. All the participating laboratories were required to report suspicious pathogens and given antibiotics susceptibility .The data analyzed and evaluated . Results : The accurate rates of detected resistant strains of 489 bacteria laboratories in China were as follows; Oxacillin susceptible stapby-lococcusaureus (MSSA) 74%, Qxacillin resistant coagulase-negative staphylococci (MRSCoN) 48 %, Penicillin unsusceptible pneumococ-ci 7%, aminoglycosides high - level resistant enterococcus 95% , detecting β-lactomase producing 35%. Conclusion: The EQA program of AST showed that the ability of detecting antibiotic resistance of most bacteria laboratories in China should be improved.