摘要
目的研究met-RANTES对同种异体大鼠耳廓移植后移植物的生存时间、组织形态学改变及免疫细胞浸润的影响。方法动物模型以20只SD大鼠为供体,20只WISTAR大鼠为受体(SD→WISTAR),进行耳廓移植,分为治疗组、未治疗组。治疗组术后给予趋化因子拮抗剂met-RANTES治疗,未治疗组给予相同剂量的生理盐水。然后观察耳廓的生存情况、组织学变化与免疫细胞的浸润。结果治疗组移植耳廓的生存时间明显延长,组织中T淋巴细胞的浸润,组织结构的改变均明显好于未治疗组。结论趋化因子拮抗剂met-RANTES可以显著的抑制免疫排斥反应,延长移植耳廓的生存时间。
Objective TO study met-RANTES effect on survival time ,histologic changes and recruitment of inflammatory cells in rat auricle allograft.Method Rats included 20 SD rats as donors and 20 WISTARs as recipients,which were divided into two groups,treatment group and non-treatment group.Rats in treatment group were injection with met-RANTES every day after operation, and rats in non-treatment one were given saline.The survival time of rat auricle and pathological changes and recruitment of inflammatory cells were checked.Result The survival time of rat auricle allografts was prolonged, and pathological changes and recruitment of inflammatory cells of treatment group were better than non-treatment one.Conclusion Met-RANTES can significantly prolong rat auricle allografts survival time, decrease rat auricle allograft rejection.
出处
《中国临床康复》
CSCD
2002年第2期214-214,216,共2页
Chinese Journal of Clinical Rehabilitation
基金
国家自然科学基金资助重点项目(39993430-2)
