氟西酊合并小剂量阿密替林治疗抑郁性神经症的对照研究

A comparative study of fluoxetine with a little dose of amitriptyline in treating depressive neurosis

目的观察比较氟西酊合并小剂量阿密替林治疗抑郁性神经症的效果和副作用。方法在心理康复门诊中对符合CCMD-2-R诊断标准且SDS评分≥40分的抑郁神经症病人69例,随机分为常规剂量的氟西酊组、阿密替林组和氟西酊合并小剂量阿密替林组。每组于治疗前,治疗后2周、4周和8周共4次行SDS和SAS评定以及治疗期间副作用发生率评定。结果氟西酊合并小剂量阿密替林治疗抑郁性神经症显效率为95%。治疗期间其副作用与氟西酊组相仿,但明显较阿密替林组轻且发生率低。结论氟西酊合并小剂量阿密替林具有明显抗抑郁和抗焦虑作用,对抑郁性神经症疗效较理想,且副作用较少。

Objective To observe and compare the effect and the side-effect of fluoxetine with a little dose of amitriptyine in treating depressive neurosis.Methods 69cases patients in out-patient dep artment who were diagnosed as depressive neurosis according to CCMD-2-R and whose scores of Self-Ra ting Depression Scale(SDS)were not lower than 40were randomly d ivided into three groups-the rotine dose of fluoxetine group,the amitriptyline group and the group of fluoxetine with a little dose of amit riptyine.Four times SDS and SAS evaluation were given to all the p atients in each group at the time of before the treatment and at the second,the fourth and the eighth week of the treatment.Meanwhile,th e side-effect of all the treatment we re recorded.Results The antidepressant efficacy of fluoxetine with a little dose of amitriptyline was 95%,which was significantly higher th an that of the fluoxetine group which was 76%and amitriptyline group which was 75%(P<0.05).The side-effect of the fluoxetine w ith a little dose of amitriptyine gro up during the treatment were similar to that of the fluoxetine gro up,but significantly fewer than that of the amitriptyline group.Conclusion The treatment of fluoxetine with a little dose of amitriptyline h as a significant effect of antideprs sion and antianxiety with fewer side effect,and should be an ideal method in treating depressive neuro sis.