3-甲氧基-4-羟基苯甲醛肟的合成

Synthesis of 4-hydroxy-3-methoxyphenyl Oxime

以香兰素、盐酸羟胺和强碱为原料 ,制备出了 3 甲氧基 4 羟基苯甲醛肟。影响合成反应过程的因素有 :温度、试剂的加入顺序、不同的强碱及三种原料的摩尔比。正交实验后三种原料的最佳摩尔比为 1:1 2 :1 1,产物的产率达 97 4 %。文中还对不同酸碱度条件下的此反应机理进行了探讨。通过反应产物熔点的测定及其IR、1HNMR、TIC MS等的分析 。

The synthesis of 4 hydroxy 3 methoxyphenyl oxime has been made from vanillin, hydroxylamine hydrochloric acid and sodium hydroxide The factors of reaction process include theses,such as temprature, reagents, strong bases and mole rate of three crude materials The results show that the best mole rate of three reagents is for 1:1 2:1 1,and the product ratio is for 97 4% The reactive process and mechanism of synthesis has been discussed The synthesis product has been corroborated after the measurement of melting point and analysis of its IR, 1HNMR,TIC MS