恩诺沙星和环丙沙星对金葡菌的抗菌后效应及抗菌后亚抑菌浓度效应

Postantibiotic Effect and Postantibiotic sub-MIC Effect of Enrofloxacin and Ciprofloxacin against Staphylococcus aureus

报告了抗菌后效应 (postantibiotic effect,PAE)、抗菌后亚抑菌浓度效应 (postantibiotic sub- MIC effect,PASME)、亚抑菌浓度效应 (sub- MIC effect,SME)研究的方法学和恩诺沙星、环丙沙星对金葡菌抗菌后效应及抗菌后亚抑菌浓度效应的研究结果。试验表明 :2、4MIC的恩诺沙星对金葡菌的 PAE为 1.0 3、1.5 0 h,1/2、1、2、4MIC的环丙沙星的 PAE为 0 .5 1、0 .88、1.47、1.92 h;1/8、1/4、1/2 MIC的恩诺沙星对经 4MIC药物诱导 1h的金葡菌可产生0 .38、1.15、>12 .31h的 PASME,1/8、1/4、1/2 MIC的环丙沙星的 PASME为 2 .6 9、>10 .17、>13.17h;1/8、1/4、1/2 MIC的恩诺沙星和环丙沙星对金葡菌产生的 SME分别为 0 .40、0 .91、>9.44 h和 0 .42、1.14、>9.0 2 h。上述结果说明 ,PAE、PASME和 SME的大小与药物浓度呈正相关 。

In this study,the methodologies of postantibiotic effects(PAE),postantibiotic sub-MIC effect(PASME) and sub-MIC effect(SME) were established and relevant results of enrofloxacin and ciprofloxacin against Staphylococcus aureus were obtained.At two and four times the MIC,PAEs of enrofloxacin were 1.03 and 1.50 h,and the PAEs of ciprofloxacin at 1/2,1,2 and 4 MIC were 0.51,0.88,1.47 and 1.92 h,respectively.After exposing to the drugs at four times the MIC for 1 hour,the S.aureus suspension continued the exposure to 1/8,1/4 and 1/2 MIC and resulted in average PASMEs of 0.38,1.15 and >12.31 h,respectively,for enrofloxacin and 2.69,>10.17 and >12.31 h,respectively,for ciprofloxacin.The SMEs for enrofloxacin at 1/8,1/4 and 1/2 MIC were 0.40,0.91 and >9.44 h,respectively and for ciprofloxacin 0.42,1.14 and >9.02 h,respectively.The results showed that length of PAE,PASME,and SME of the two drugs were in dose-dependent manner,and ciprofloxacin seemed to exhibit longer effects than enrofloxacin against S.aureus.