先兆早产患者宫颈粘液IL-6、6-酮-PGF_(1α)和TXB_2水平与羊膜腔感染的关系

Relationship Between Concentrations of IL-6、6-keto-PGF_(1α) and TXB_2in Cervical Mucus of Patients with Threatened Preterm Labor and Intraamniotic Infection

目的 :通过测定先兆早产患者和对照组的宫颈粘液 IL - 6、6 -酮 - PGF1α、TXB2 水平和胎盘病理检查 ,探讨此三种物质及后两者比值与组织学绒毛膜羊膜炎的关系。方法 :采用放射免疫分析方法测定 2 5例先兆早产患者宫颈粘液 IL-6、6 -酮 - PGF1α、TXB2 浓度 ,胎盘病理检查有无组织学绒毛膜羊膜炎 ,并与未足月对照组、足月对照组进行比较。结果 :先兆早产组组织学绒毛膜羊膜炎发生率高于足月对照组 (P<0 .0 0 1)。先兆早产组有组织学绒毛膜羊膜炎者宫颈粘液IL- 6、6 -酮 - PGF1α、TXB2 浓度均高于无组织学绒毛膜羊膜炎者 ,而 6 -酮 - PGF1α/ TXB2 比值降低 (P<0 .0 5 )。先兆早产组与未足月对照组比较 ,宫颈粘液 IL- 6、TXB2 升高 (P<0 .0 5 ) ,6 -酮 - PGF1α无显著性改变 (P>0 .0 5 ) ,6 -酮 - PGF1α/ TXB2 比值降低 (P<0 .0 5 )。结论 :先兆早产伴组织学绒毛膜羊膜炎患者宫颈粘液 IL - 6、6 -酮 - PGF1α、TXB2 浓度明显升高 ,而 6 -酮 -PGF1α/ TXB2 比值降低 。

Objectives:To investigate the relationship between concentrations of IL 6,6 keto PGF 1α and TXB 2in cervical mucus of patients with threatened preterm labor and histologic chrioamnionitis,and determine whether they predict subclinical intraamniotic infection.Methods: Cervical mucus was obtained from 25 patients with threatened preterm 1abor,the concentrations of IL 6,6 keto PGF 1α and TXB 2were determined by radioimmunoassay(RIA).Placental histologic study was performed in those patients delivered prematurely.All the results were compared with preterm and term control groups.Results: The prevalence of histologic chorioamnionitis in threatened preterm labor group was higher than term control group( P <0.001).In threatened preterm labor group,patients with histologic chrioamnionitis had significantly higher median cervical mucus IL 6,6 keto PGF 1α and TXB 2 concentrations and lower 6 keto PGF 1α /TXB 2ratios than patients without histologic chorioamnionitis( P <0.05).Patients with threatened preterm labor had higher IL 6,TXB 2levels in cervical mucus and lower 6 keto PGF 1α /TXB 2ratios than preterm controls( P <0.05),whereas the levels of 6 keto PGF 1α had no significant change( P >0.05).)Conclusions: The elevated cervical mucus IL 6 ,6 keto PGF 1α and TXB 2concentrations and decreased 6 keto PGF 1α /TXB 2ratios were found in patients with threatened preterm labor with histologic chorioamnionitis,they can serve as markers of subclinical intraamniotic infection in patients with threatened preterm labor.