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甘丙肽与癫癎 被引量:2

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摘要 甘丙肽(galanin,GAL)是一种广泛分布在神经系统的神经肽,具有广泛的神经生物学功能。主要参与下丘脑神经内分泌调节,与摄食行为密切相关,对学习和记忆有明显抑制作用。海马中GAL免疫活性细胞极少,但海马接受大量来自隔区、蓝斑及下丘脑的GAL免疫活性纤维投射。海马内的GAI通过抑制海马CAI区锥体细胞的兴奋性突触后电位,抑制兴奋性氨基酸的释放,开放ATP依赖性K+通道而发挥其抗癫(?)作用。遗传诱导的GAL表达变化可调节海马的兴奋性从而决定癫(?)发作的倾向。
作者 徐向平
出处 《国外医学(儿科学分册)》 2002年第3期127-128,共2页 Foreign Medical Sciences(Section of Pediatrics)
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