异种移植组织相容性及免疫动态变化测试模型

ANIMAL MODEL OF IMMUNOLOGIC CHANGE DETECTION IN VIVO AFTER XENOTRANSPLANTATION

目的 综述异种移植物抗宿主反应 (GVHD)动物模型的研究现状、检测方法及进展情况。方法 采用文献回顾与综合分析方法。结果 免疫活性细胞植入异种受者体内后 ,有发生排斥 (HVGD)、移植物抗宿主反应(GVHD)和微嵌合的可能 ,异种 GVHD已在小动物和大动物体内成功诱导 ,并可通过多种途径进行检测。结论 异种GVHD大动物模型 ,主导因素是嵌合细胞 。

Objective To review the current condition, test method and progress of the animal model of xeno graft versus host disease(xeno GVHD). Methods The literature review and comprehensive analysis methods were used in this article. Results Implanted immunologic cells, the recepient had the chance of showing host versus graft reaction, GVHD or microchimerism. Now, xeno GVHD could be induced in vivo at small and large animals, it also could be supervised through many ways. Conclusion Chimeric cells is very important to xeno GVHD animal model. With this model, we can really mimic the immunologic change in vivo after xenotransplantation.