黄磷对大鼠肝微粒体Ca^(2+)泵的影响

The Effect of Yellow Phosphorus on Calcium Pump in Rat Liver Microsome

用离体实验和整体动物实验方法,发现不同浓度的黄磷对大鼠肝微粒体Ca^(2+)-ATP酶和^(45)Ca摄取有不同程度的抑制作用,并有随剂量增大而抑制作用加重的趋势,提示微粒体Ca^(2+)泵的损害在黄磷中毒性肝损害中具有重要作用。

This paper showed that yellow phosphorus of various concentrations had an inhibitive effect on Ca2+-ATPase and calcium uptake of rat liver microsome both in vitro and in vivo. The inhibitive effect tended to be more severe with the increase of dose. The result suggested that the impairment of calcium pump of liver microsome plays an important role in phosphorus-induced hepatotoxicity.