对氨基水杨酸钠对氯化锰染毒大鼠脑单胺递质的影响

The Effects of PAS-Na on the Levels of Monoamine Neurotransmitter in Different Brain Regions of Manganese Exposed Rats

本文报道了对氨基水杨酸钠(PAS-Na)对氯化锰腹腔注射染毒大鼠脑单胺递质水平的影响。PAS-Na能使锰染毒所降低了的脑多巴胺(DA)水平逆转;锰使脑去甲肾上腺素(NE)含量增加,染毒后以PAS-Na治疗则使之进一步升高;锰染毒和染毒后治疗组的5-羟色胺(5-HT)及5-羟吲哚醋酸(5-HIAA)的变化与DA相似,但PAS-Na使5-HT、5-HIAA水平升高的幅度大都较NE和DA的要小,提示5-HT能神经元对PAS-Na治疗作用的敏感性低于儿茶酚胺(CA)能神经元。

The effect of PAS-Na treatment was investigated in rats after the daily ip with MnCl2 ?4H2O (15mg/kg/day ) for a period of 12 weeks. The contents of dopamine ( DA ) , norepinephrine ( NE ) , serotonin ( 5-HT ) and 5-hydroxyindoleacetic acid(5-HIAA ) were measured in several brain regions ( cerebral cortex, striatum, hypthalamus and 'rest of the brain' by fluorospectrophotometry. The results showed that a significant decrease in the concentration of DA in striatum and cerebral cortex, 5-HT in brain, and 5-HIAA in striatum of rats after manganese exposure was produced, NE significantly increased in striatum and hypthalamus of the same group of animals. It is of interest to note that treatment with PAS-Na resulted in an elevation in the levels of DA, NE, 5-HT and 5-HIAA in the most brain regions of the rats exposed to manganese. The increased levels of 5-HT and 5-HIAA are mostly lower than that of NE and DA, suggesting the serotonergic neurons to be less sensitive to PAS-Na effects than catecholaminergic ones.