硫酸锌对大鼠毒性的某些生物化学和病理学研究

The Biochemical and Pathological Studies on the Toxicity of Zine Sulfate in Rats

硫酸锌对大鼠的急性毒性属低毒物质,对小鼠属中等毒性物质。大鼠90天喂养试验硫酸锌摄入量为68.5mg/kg及其以上时,血清铜蓝蛋白活性明显降低,血清铁和高密度脂蛋白胆固醇降低,肾脏和睾丸出现多种病变,如肾小球肿胀和蛋白管型等,睾丸基膜增厚和间质细胞增生等。摄入量在19.5mg/kg及其以下时,不产生任何毒性作用。提示硫酸锌的最大无作用剂量为19.5mg/kg。

In this paper, acute and subchronic toxicity of Zine Sulfate in rats was studied The results showed that the scute toxichy of Zinc Sulfate. on rats vat lover. In autopsy, erosion of gastric mu-cosa of rats was found. In subchronic toxic experiment on rats taking 58.5mg/kg b. w. of Zine Sulfate, ceruloplafmins were significantly decresed ( p<0.05) , the type and degree of pathological changes in the kidneys and testes were significantly increased (p<0.05 ) , such as glomerular swelling and protein casts in kidneys, the hyperplasia of basilar membrane and mesenchymal cells in testes etc. Zine Sulfate at oral 19.5mg/kg b. w. in rats did not produce any toxic effect, therefore maximal no-effect level (M. N. L) of the Zine Sulfate was 19.5mg/kg b. w. The results provided pathological and biochemical evidences for the acceptable daily intake (A. D. I) of food.