冕宁地区克山病患者发硒含量的调查分析

A case-control study on the selenium of Keshan Disease patients

目的 进一步探讨地方性低硒在克山病病因学中的作用。方法 在 1995— 1999年度内 ,对 32例新发克山病病例 ,按 1∶ 2配对 ,对头发硒含量进行对比分析。结果 病例组与内对照组 (患者亲兄妹 )和外对照组(患者同龄近邻 )的发硒平均值分别为 0 .0 776 ,0 .12 79和 0 .1313μg/ g;病例组与对照组发硒值的组间差异有显著意义。结论 在全国克山病病区的病情普遍呈多年低发病率后 。

Objective To explore the role of endemic low selenium in the etiology of Keshan disease.Methods A group of 32 Keshan Disease patients occurred in 1995-1999 in a Keshan disease endemic area were paired both with their siblings (M1) and their neighbor children (M2) at the sane age as subjects.Hair was collected and hair selenium was analyzes.Results The average hair selenium content of patients and control in group M1 and group M2 were 0.077 6,0.127 9 and 0.131 3 μg/g,respectively.There were significant differences between the hair selenium contents of patients and controls.Conclusions The results showed that after the incidence of Keshan disease has been decreased in China for many years,the low selenium environment leading to low selenium in the diets of Keshan disease endmic arease may still be one of the factors causing Keshan disease.