一氧化氮与实验性病毒心肌炎及扩张心肌病

Nitric oxide and laboratory virus myocarditis and dilated cardiomyopathy

一氧化氮 (nitric oxide,NO)是一种具有多种功能的生物活性分子 ,在实验性病毒性心肌炎与扩张性心肌病的病变中具有双重生物效应 :低浓度的 NO可抑制病毒的复制和细胞凋亡 ,从而保护心肌细胞 ;但高浓度的 NO具有细胞毒和负性肌力作用 ,在实验性病毒性心肌炎及扩张性心肌病心肌损伤。

Nitric oxide (NO) is a small molecule with multiple functions, which is known to play a bifunctional role in the pathogenesis of laboratory virus myocarditis and dilated cardiomyopathy. The low level NO could inhabit the virus reproduction and cell apoptosis. It protects myocardial tissues.However, the high level NO is related to the occurrence and development of the myocardia injury, the low stroke volume, the heart failure of laboratory virus myocarditis and dilated cardiomyopathy because of its cytotoxic and negative in tropic actions.