骨质疏松相关基因在骨质疏松中的作用

The effects of osteoporosis related genes on the development of osteoporosis

骨质疏松 (osteoporosis OP)是以骨质量的丢失以及骨组织的退变为特征的骨代谢疾病。近年来 ,骨质疏松相关基因如 :维生素 D受体 (VDR)基因型 ,雌激素受体 (ER)基因型 ,I型胶原 A1(COL IA1)基因型 ,骨钙素基因 ,白细胞介素基因等在骨质疏松的形成和转归方面的作用日益成为人们关注的焦点。雌激素可以增加破骨细胞的产物—转移生长因子 β1(TGF- β1)在骨中富含 ,对病人带有的 T等位基因发挥作用。中国妇女的 BMD与VDR基因型有关。白细胞介素 1(IL- 1)是促进破骨细胞的骨吸收作用因子 ,它随雌激素的减少而增加。在成骨细胞中近似于对雌激素的受体后效应 ,还可以促进破骨细胞凋亡 ,这种多效性维持着骨的稳态 (hom eostasis)。

Osteoporosis (OP) is a bone metabolic disease in a characterized by bone mass loss and its tissue regressive changes.Recently,the genes related such as VDR(Vitamin D receptor) gene,ER(Estrogen receptor) gene,CoLIA1(Collagen IA1),osteocalcin gene and IL 1 gene are emphasized by bio medical scientists because of these genes resulting in OP development and its therapy.Estrogene may induce osteoclast producing transforming growing factor β1(TGF β1) rich in bone tissues,which conducts in T allele gene of the OP patient.Bone mineral density (BMD) of Chinese women is related to VDR.IL 1 is a factor,which makes bone resorption decreasing,mediated by osteoclast with estrogen.