黄磷中毒性肾上腺皮质损害的研究

Experimental Study on Yellow Phosphorus-Induced Adrenal Cortex Injury

实验结果表明,黄磷急性中毒血浆皮质酮波动在正常水平,亚急性中毒早期下降,以后恢复正常,肾上腺抗坏血酸含量无异常;组织学检查可见肾上腺皮质束状带细胞肿胀透亮,部分细胞边界不清,核消失,脂质减少;电镜下可见束状带细胞浆电子密度降低,出现大量髓鞘样体,线粒体后期消失,与此同时,肝脏已呈明显损害。认为黄磷在引起肝损害同时,可能直接影响皮质激素的生物合成;肝损害影响皮质激素在肝的代谢,故血浆皮质激素水平波动在正常水平或下降。

The results showed that in acute experiment the concentration of blood corticosterone had ranged within normal level. However, in subacute experiment it appeared to be decreased in the early stage but recovered to normal level in the later stage. No change was shown in term of ascorbic acid in adrenal. Otherwise, yellow phosphorus appeared to be able to cause swelling and transparence of adrenal cortex cells, partly with unclear boundaries and lipid deficiency. Under EM observation, it was shown in the zona fasciculate that reduction of electron-dense and appearance of a number of myelin-like material. The mitochondria seemed to be disappeared in the later stage. Under the same condition, obvious injuries of liver were displayed. It was considered that yellow phosphorus might simultaneously cause liver damage and hindrance to biosynthesis of cortical hormones. The liver injury induced by yellow phosphorus might affect the metabolism of cortical hormones, so that the concentration of blood cortical hormones ranged in normal level or decreased.