肝再生刺激因子加表皮生长因子治疗小鼠中毒性肝坏死

TREATMENT OF TOXIC HEPATIC NECROSIS IN MICE WITH HEPATIC STIMULATOR SUBSTANCE PLUS EPIDERMIC GROWTH FACTOR

小鼠350只随机均分7组,给各组小鼠(除对照组及NaCl组外)ip 900mg/kg的醋氨酚(AAP)致小鼠中毒性肝坏死后,分别用消炎痛、氢化可的松琥珀酸钠(HC)、肝再生刺激因子(HSS)、表皮生长因子(EGF)、HSS+EGF等治疗。结果NaCl组鼠死亡率98％,消炎痛组100％,HC组58％,EGF组18％,HSS缉16％,HSS+EGF组2％,提示HSS+EGF对鼠中毒性肝坏死有良好的治疗效果。

350 mice were randomly divided into seven groups. Acetaminophen ( AAP, 900 nig/kg, i.P. ) was given to each mouse of every group to induce a toxic necrosis of the liver, then mice were treated with Indbniethecin, Hydrocof tisoni Natrii Succinas(HC), hepatic stimulator substdnee(HSS), epidermic growth factor(EGF), and HSS + EGF, respectively. The results showed that the mortality of the NaCl group was 98%, Indomethecin 100%, HC 58%, EGF 18%, HSF 16% and HSF+EGF 2%, respectively. It suggested that HSS + EGF had excellent curative effects in mice with toxic necrosis of the liver.