摘要
用氢化钠中的负氢攻击乙酸乙酯分子中的α位氢原子 ,形成负碳离子 ,再与间氯苯甲酰氯(Ⅱ )分子中的甲酰基发生定向缩合反应 ,生成间氯苯甲酰乙酸乙酯 (Ⅲ ) ;将Ⅲ水解得间氯苯甲酰乙酸(Ⅳ )和乙醇 ;最后再将 (Ⅳ )脱羧 ,即生成间氯苯乙酮 (Ⅰ )。合成反应在常压和 6 0～ 110℃温度下进行 ,反应物 (Ⅱ )转化率≥ 90 % ,产物 (Ⅰ )得率≥ 80 %。
Utilizing hydrogen anion of hydrogen sodium attacks α hydrogen atom of ethyl acetate to form anionic carbon. Then condensation reaction is taken place between the anionic carbon and formyl of m chlorobenzoyl chloride(Ⅱ),to produce m chlorobenzoyl ethyl acetate(Ⅲ) which hydrolyzes with the product m chlorobenzoyl acetic acid(Ⅳ) and ethanol. At last the product(Ⅳ) is transformed into m chloroacetophenone(Ⅰ) with the action of decarboxylizing.The reaction is carried out under common atmosphere and at the temperature from 60℃ to 110℃. The transformation rate of(Ⅱ)is over 90%. The yield of (Ⅰ) is more than 80%.
出处
《化工科技》
CAS
2002年第1期4-7,共4页
Science & Technology in Chemical Industry
关键词
间氯苯甲酰氯
氢化钠法
合成
间氯苯乙酮
m Chloroacetophenone
Synthesis
m Chlorobenzoyl chloride
Sodium hydride
