XW630对去势大鼠骨组织力学性能及骨小梁结构参数的影响

Effect of XW630 on mechanical properties and trabecular structure parameters of bone tissue in ovariectomized rats

目的 探讨抗骨质疏松新药XW6 30对去势大鼠骨组织力学性能及骨小梁结构参数的影响。方法 3月龄SD雌性大鼠 36只 ,随机分为Sham组、OVX组、OVX +CFT组和OVX +XW6 30组 ,每组 3只。取左侧股骨作三点弯曲力学强度测试 ,左侧胫骨作骨小梁结构参数测定。结果 整个观察期内 ,OVX组股骨三点弯曲强度呈下降趋势 ,与Saham组存在显著性差异 (P <0 0 1) ,两个治疗组骨强度则呈上升趋势 ,与OVX组存在显著性差异 (P <0 0 5和P <0 0 1)。胫骨骨小梁结构参数测定结果显示 ,OVX组骨形成参数 (Vv、Tb .Th、Tb .N)逐渐下降 ,而骨吸收参数 (Tb .Sp)逐渐增加 ,呈骨量丢失状态 ,而两个治疗组骨形成参数逐渐增加 ,骨吸收参数逐渐下降 ,与OVX组之间存在显著性差异 (P <0 0 5和P <0 0 1)。两个治疗组同期各项测定结果无显著性差异 (P >0 0 5 )。结论 XW6 30能有效地促进去势大鼠骨组织的成骨和预防骨质疏松性骨折的发生 。

Objective\ To investigate the effect of anti\|osteoporostic new drug XW630 on mechanical properties and trabecular structure parameters of bone tissue in ovariectomized rats. Methods\ Thirty\|six female SD rats,three months old,were randomly divided into sham\|operated group(sham),ovariectomized group(OVX),esterone\|therapy group(OVX+CFT) and XW630\|therapy group (OVX+XW630).Three rats in each group were killed at 30,60,90 days after operation.The left femora were taken for three\|point bending resistance tests,and left tibias were taken for trabecular structure parameter tests. Results\ During the observation period,the three\|point bending resistance of OVX group gradually decreased and there was a significant difference compared with sham group( P <0\^01),while the three\|point bending resistance of two therapy groups gradually increased,which was significantly different from that of OVX group ( P <0 05 and P <0 01).Results of trabecular structure parameter tests showed that Vv,Tb.Th,Tb.N gradually decreased while Tb.Sp gradually increased in OVX group,which indicated the state of bone loss.There were significant differences between OVX group and two therapy groups ( P <0 05 and P <0 01),of which the bone formation parameters increased and bone absorption parameters decreased gradually.At the same stage,there was no significant difference between OVX+CFT group and OVX+XW630 group( P >0 05). Conclusion\ XW630 can effectively promote osteogenic action and prevent osteoporostic fracture in ovariectomized rats,which indicates a widspread prospect in use of XW630 as a new anti\|osteoporosis drug.