慢性抑郁症的临床特征对照分析

An controlled analysis of clinical characters of 43 cases with chronic depression.

目的 探讨慢性抑郁症患者的临床特征。方法 对 2 5 8例住院抑郁症患者的有关临床资料进行回顾性调查。结果 有 43例 (16 .7%)为慢性抑郁症患者 ;同非慢性者相比 ,其结果为慢性者多在 2 5岁前起病 ,具神经质人格 ,病前多有负性生活事件及躯体疾病 ,且有明显的认识障碍及焦虑躯体化症状 ,较多伴有精神病性症状 ;经逐步回归分析 ,影响患者病程慢性化的主要因素为 :病前神经质人格、负性生活事件、社会支持系统、精神病性症状。结论 抑郁症预后并不乐观 ,应加强社会心理因素的干预。

Objective To explore the clinical characters of chronic depressive patients.Methods The relevant clinical data of 258 patients with depression in hospital were reviewed.Results 43(16.7%)patients with chronic depression were compared with non-chronic group.Chronic group had more onset of disease before 25 years,neurotic personality,more negative life events and premobid physical disease,clear cognitive disorder,anxiety-somatization symptoms and more accompanying psychotic symptoms.Stepwise regression analysis showed the main risk factors contributing to the chronic course of disease were premobid neurotic personality,negative life events,the social support and psychotic symptoms.Conclusion The prognosis of depression was not allow optimism.It was important to strengthen the intervention of the social psychogenic factors.