有无家族史抑郁症的临床特征比较

Comparison of clinical characters between depressed patients with and without family history of psychosis.

目的研究有无家族史抑郁症的临床差异。方法收集首次住我院的抑郁症病例，对照ＣＣＭＤ－２－Ｒ再诊断及随访，对资料完整的１０２例按有无家族史分组对照分析。结果家族史阳性者占３０．３９％，其中女性比例并不占优势，发病季节性亦不明显，病前生活事件显著少于家族史阴性组，三年随访复发率显著高于家族史阴性组，临床症状与住院疗效两者相仿。结论阳性家族史是抑郁症易发病的重要因素之一，家族史阴性者应重视生活事件等对疾病的促发作用。尚无充足理由依据家族史对抑郁症分型。

ObjectiveTo compare the clinical characters of depressed patients with and without family history of psychosis.Method102 depressed patients at first hospitalization diagnosed according to CCMD-2-R and followed up were divided into two groups by family history.ResultsThe rate of positive family history in depression was 30.39%.There was no significant difference in the female rate and the season of onset between the two groups,but the positive group showed significant less in events before onset and significant higher in the relapse rate by three-year follow-up.The two groups had the same clinical symptoms and hospital response.ConclusionsFamily history is one of the main onset effects in depressed patient.To depressed patients without family history,we should pay more attention to life events as a promotive effect.But there is not enough reason to divide depression into different subtypes by family history.