速溶山楂饮料对高脂血症患者血脂、抗氧化酶和免疫功能的作用

The effects of an instant haw beverage on lipid levels,antioxidant enzyme and immune function in hyperlipidemia patients

目的 探讨速溶山楂饮料调节高脂血症患者脂质紊乱、提高抗氧化酶活力和增强免疫功能的作用。方法 6 0名年龄 (5 7 9± 8 0 )岁高脂血症受试者 ,采用交叉试验方案 ,每名受试者参加 2次试验。半数受试者于第 1次试验补充速溶山楂饮料 (含 3g山楂干粉、相当于 30g鲜果 ,溶于 10 0ml水及饮料载体 ,1d 2次 ) ,另半数补充对照液 (0 75g瓜儿胶和少量淀粉作为饮料载体 ,1d 2次 )。持续 31d ,间隔 2 8d后 ,开始第 2次试验 ,受试者原补充速溶山楂饮料者 ,改为对照 ;原补充对照改为速溶山楂饮料。结果 补充速溶山楂饮料能显著降低血清总胆固醇 (9 6 % )、甘油三酯 (12 1% )、低密度脂蛋白 (18% ) ;而明显增加超氧化物歧化酶 (SOD)活力 (7 5 % )水平。受试者补充含瓜儿胶对照液虽然对某些血清脂质也有一定的改善作用 ,但效果不如速溶山楂饮料显著 ;而且 ,受试者仅在补充速溶山楂饮料时血清甘油三酯水平显著降低、抗氧化酶SOD水平显著提高 ,补充对照液无作用。结论 补充速溶山楂饮料能有效降低血清总胆固醇、甘油三酯、低密度脂蛋白、丙二醛水平 ,升高ApoA Ⅰ水平、SOD活性和NK细胞活力 ;综合测试表明 :补充速溶山楂饮料和对照比 ,调整血脂、提高抗氧化酶活力效果更显著。

Objective To determine the effectiveness of an instant haw beverage in regulating lipid disturbance, enhancing antioxidant enzyme activity and immune function Methods Data was collected from 60 hyperlipidemic subjects In this crossover design, each subject randomly received either the instant haw beverage (100 ml corresponding to 3 g of haw powder or 30 g of fresh haw fruit plus the carrier?-guar gum plus some starch) or placebo (guar gum 1 5 g plus some starch as the carrier of the beverage) twice daily Each supplementation lasted 31 days with a 28 day washout period between treatments Results The instant haw beverage significantly reduced total serum cholesterol(9 6%), triglyceride (12 1%), LDLC (18%) while significantly increased SOD activities(7 5%) The placebo was shown to have positive results in some of the lipid profiles, though the effects of the instant haw beverage demonstrated greater significance Serum triglyceride levels were significantly decreased and SOD activity significantly increased only as subjects were supplemented with the instant haw beverage while no significant changes were seen with placebo Conclusion Supplementation with the instant haw beverage positively affects blood lipid profile, antioxidant status and immune function in individuals with hyperlipidemia