摘要
目的 研究 2型糖尿病与遗传和环境因素的相互关系。方法 对江苏省 1997年糖尿病流行病学调查中 ,筛选出的 2型糖尿病患者 15 4例及与其性别、年龄构成相近的正常人群对照 130例进行单因素和多因素非条件logistic回归分析。结果 年龄、糖尿病阳性家族史、高血压史、腰臀比大、收缩压、女性巨大胎儿史及 β3 肾上腺素能受体基因变异是 2型糖尿病的危险因素 ,职业性体力劳动是其保护因素 ;遗传因素与肥胖、β3 肾上腺素能受体基因变异等危险因素共同存在时 ,糖尿病的发病危险性 (OR)将明显增加。结论 2型糖尿病是遗传因素与环境因素共同作用的结果。
Objective To study the relationship between the inheritable factor and environmental factors of type 2 diabetes mellitus in humans. Methods A case control study based on 154 type 2 diabetes mellitus and 130 healthy controls was carried out in Jiangsu Province in 1997. Results The age, family history of diabetes mellitus, hypertension history, high waist/hip ratio(WHR),high systolic blood pressure, huge fetus history, and the genotype of β 3 adrenergic receptor(β 3 AR)were the risk factors of type 2 diabetes mellitus; while occupational physical activity was protective factor of type 2 diabetes mellitus. The risk for diabetes mellitus distinctly increased while genetic factor and obesity, β 3 AR mutation were coexisting. Conclusion Type 2 diabetes mellitus is caused by the effect of both genetic and environmental factors.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2002年第3期191-194,共4页
Chinese Journal of Preventive Medicine
