孕妇巨细胞病毒激活感染及对胎儿影响研究

Study on Risk Factors of HCMV Reactivate Infection in Pregnancy and Influence on Fetus

目的 探讨孕妇巨细胞病毒激活感染的危险因素及对胎儿的影响。方法 收集孕妇血清标本351份,母婴血清标本245对,检测HCMV-IgM抗体。并对孕妇的年龄、孕次、产次及病理性流产史等因素进行调查,观察对婴儿的影响。结果 上述因素对HCMV激活感染有一定作用,其中孕次是激活感染的危险因素。孕妇激活感染可影响胎儿发育,引起胎儿生长发育迟缓,新生儿呈低体重,多种脏器均有HCMV包涵体及病毒颗粒。在孕早期能使胎儿发育受阻而产生难免流产。结论 减少怀孕次数有利于优生优育,避免早期的HCMV激活感染,可减少流产及畸形儿出生。

ve To investigate the risk factors ot HCMV reactivate infection in p regnancy and the influence to fetus. Methods To collect 351 sera samples of pregnant women, 245 pairs of sera samples of puerpera and their infants to detect HCMV- IgM;inquire the age, the number of pregnancy and delivery as well as abortion history in order to see the influence on the infants. Results These factors may relate to HCMV reactivation, among them the number of pregnancy is the risk factor. HCMV reactivation affect fetus development, result in growth lagging, lower body weight of the new - born and the detection of HCMV particles and specific inclusion body in several organs. In the early stage of pregnancy cease the growth of fetus and cause abortion. Conclusion To reduce the number of pregnancy is eugenic, avoiding HCMV reactivate infection in the early stage of pregnancy can reduce the accurance of abortion and malformation.