流行性感冒疫苗的免疫效果观察

Evaluation on Immune Effect of Influenza Vaccine

目的 为了解流行性感冒（流感）疫苗免疫效果及安全性。方法 1999年1～2月在杭州市192名7～9岁儿童进行了疫苗接种前后免疫水平观察。结果 甲1型（H2N2）、甲3型（H3N2）和乙型流感HI抗体阳性保护率分别由1.56％、53.13％、52.60％上升到82.81％,87.50％和97.92％;平均抗体增长幅度分别是免疫前的18.9,2.9和5.69倍。副反应发生率为1.6％。结论 证实流感疫苗具有良好的免疫效果和安全性,值得进一步推广应用。

ve To observe the immune effect and safety of influenza vaccine. Methods These 192 children aged between 7-9 years old in Hangzhou were vaccinated from Jun. to Fed of 1999 and evaluated their immunity level before and after vaccination. Results The result showed that positive seroconversion rates of anti - H1N1, anti - H3N2 and anti- HI were raised respectively from 1.56%,53. 13% and 53.60% to 82. 81% , 87. 50% and 97.92%,and antibody density increased respectively 18. 9,2.9 and 5.79 times of seroconversion density before vaccination.The side-effect rates was 1.6% .Conclusion The study showed that influenza vaccine were worthy of popularization for its good immune effect and safety.