还原型谷胱甘肽对创伤后肝损害的治疗作用

Therapeutic effect of reduced glutathione hormone on damaged liver after trauma

目的 探讨还原型谷胱甘肽 (GSH)对创伤后肝损害的治疗作用。 方法 创伤后肝损害患者 12 8例 ,随机分为两组。治疗组 60例 ,静脉滴注GSH 1.2～ 1.8g,1次 d ,连续用 7d。对照组 68例 ,静脉滴注肌苷 1.0～ 2 .0g、维生素C 2 .0～ 3 .0g、门冬氨酸钾镁 2 0ml、茵栀黄 3 0ml,1次 d ,连续用 7d。 结果 治疗组和对照组丙氨酸转氨酶 (ALT)、天冬氨酸转氨酶 (AST)、凝血酶原时间 (PT)的显效率分别为 75 .0 % ( 4 5 60 )和 7.4 % ( 5 68) ,总有效率分别为 93 .3 % ( 5 6 60 )和3 3 .8% ( 2 3 68) ;γ -谷氨酰转肽酶 (γ -GT)、总胆红素 (TB)、直接胆红素 (DB)的显效率分别为15 .0 % ( 9 60 )和 5 .9% ( 4 68) ,总有效率分别为 78.3 % ( 4 7 60 )和 3 2 .4 % ( 2 2 68)。治疗组疗效明显优于对照组 ,两组比较 ,差异有非常显著性意义 (P <0 .0 1)。两组血清白蛋白 (ALB)的显效率分别为5 .0 % ( 3 60 )和 4 .4 % ( 3 68) ,总有效率分别为 4 8.3 % ( 2 9 60 )和 4 5 .6% ( 3 1 68) ,两组比较 ,差异无显著性意义 (P >0 .0 5 )。 结论 GSH治疗创伤后肝损害起效迅速、疗效可靠 。

Objective To study the therapeutic effect of reduced glutathione hormone (GSH) on damaged liver following trauma. Methods A total of 128 patients with damaged liver following trauma were randomly divided into 2 groups, the patients receiving GSH for 1.2-1.8 g per day through intravenous drip for 7 days as the treatment group (n = 60) and the patients receiving inosini for 1.0- 2.0 g , Vitamin C for 2.0-3.0 g, kalli magnesii aspartatis for 20 ml and Yinzhihuang for 30 ml every day through intravenous drip for 7 days as the control group (n = 68). Results The efficacy rates judged by alanine aminotransferase(ALT), aspartate aminotransferase (AST) and proturombin time(PT) were 75.0% (45/60) in the treatment group and 7.4% (5/68)in the control group with the total efficacy rates of 93.3% (56/60) and 33.8% (23/68) , respectively. The efficacy rates judged by gamma-glutamyl transpeptidase (γ-GT), total bilirubin (TB) and direct bilirubin (DB) were 15.0% (9/60) in the treatment group and 5 .9% (4/68) in the control group with the total efficacy rates of 78.3% (47/60) and 32.4% (22/68), respectively. The curative effect of the GSH in the treatment group was better significantly than that of the drugs in the control group ( P <0.01). The efficacy rates judged by albumin (ALB) were 5.0% (3/60) in the treatment group and 4.4% (3/68) in the control group with the total efficacy rates of 48.3% (29/60) and 45.6% (31/68), respectively. There was no statistical difference between the 2 groups ( P >0.05). Conclusions GSH is a rapid and effective drug in treating the damaged liver following trauma, therefore, it can be adopted as a first-selective drug.