术前应用舒乐安定和苯巴比妥钠效果比较

Effective Compare of Estazolam and Pheobartntal Pranedicated Orally

本实验硬膜外麻醉下行择期手术的成年患者120例,随机分成4组。分别给以舒乐安定4mg,2.5mg;苯巴比妥钠150mg;Vit C 500mg,术前60min口服,以消除患者术前的焦虑和紧张。测患者术前、麻醉前、术后4h的卡片记忆和收缩压、舒张压和呼吸率;计算收缩压脉率积(RPP)。按Ramsay镇静分级对患者的镇静状态进行评估。结果表明,4组中舒乐安定组2～5级者多于对照组,而麻醉实施和手术过程的记忆以及卡片法记忆明显较对照组少,且与剂量相关。因此认为术前1h舒乐安定口服4mg较使用苯巴比妥钠150mg有明显的提高镇静、增加遗忘,减少手术应激的作用,可在非胃肠道梗阻和饱胃病人中广泛应用。

Objective:To observe the efficacy of estazolam and pheobarbital premedicated orally.Methods: 120 adult patients undergoing eqidural anesthesia were randomly divided into four groups which took orally estazolam 4mg, 2.5mg; pheobarbital 150mg and Vit C 500mg ,respectively, 1h. before operation to allay anxiety and fear.Preanesthetic,Preoperative and postoperative 4hours' systolic pressure, cards memory and respiration rate were examined. Patients'calm statue was estimated with Ramsay's method. Results: The estazolam 4mg group have more sedation degree and less memory than others groups. Conclusion: To premedicate 4mg of estazolam orally before operation can obviously progress sedation,reduce stress and memory.The method can be used for curing intestinal obstruction or stomach distension.