聚(α,β-N-2-二羟乙基-DL-天冬酰胺)及其共价复合物的制备及体外缓释性能研究

A Water-soluble Polymer, Poly(α,β-N-2-dihydroxyethyl-DL-asparamide), and Conjugating Drug

目的 :制备一种新型聚天冬酰胺衍生物聚 (α,β-N -2 -二羟乙基 -DL -天冬酰胺 ) (PDHEA)。方法 :采用 GPC、F TIR、DSC等方法对该材料进行了表征 ,研究了反应条件对分子量的影响 ,并对影响其降解的因素进行了探讨。用两种方法将乙酰水杨酸键合到 PDHEA上 ,研究了不同分子量对复合体载药率及药物缓释性能的影响。结果 :该复合体释药速率稳定 ,通过调节

Poly(α,β N 2 dihydroxyethyl DL asparamide) (PDHEA) was synthesized by the ring open reaction of polysuccinimide (PSI) and diethanolamine. The polymer was characterized by infrared spectrophotometry (IR), gel permeation chromatography (GPC) and differential scanning calorimetry (DSC). Stability of the polymer was studied, which showed this material to be of high stability. The potential use of PDHEA as a drug carrier was also investigated. Acetylsalicylic acid, as a model drug was conjugated into polymers; the drug loading was over 35%. The sustained release of the drug in vitro was tested.