托吡酯治疗躁狂患者的疗效分析

Treatment efficacy of topiramate in manic patients

目的 :探讨托吡酯治疗躁狂患者的疗效。 方法 :对 5 9例躁狂、轻躁狂和混合躁狂发作的患者单用或合用托吡酯治疗 6周 ,评价疗效及副作用。 结果 :托吡酯治疗躁狂患者的有效率为 5 9.3% ;合用比单用 (6 5 .9%比 4 0 % )疗效更好 ;托吡酯治疗双相 型比双相 型、混合型、未分型疗效更好(81.8%比 5 4 .2 %、6 0 .0 %、33.3% )。不良反应有轻微静坐不能、震颤、嗜睡及胃肠道反应。 结论 :建议托吡酯治疗躁狂患者时以合用为主 ,对双相

Objective:To evaluate treatment efficacy of topiramate (TPM) for manic patients. Method:59 patients with mania, hypomania and mixed episode were treated openly with TPM for 6 weeks. The Beck Rafaelsen mania scale (BRMS),clinical global impression improvement (CGI I),TESS were used to rate treatment efficacy and adverse effects. Results:The responsive rate in manic patients was 59.3% after 6 weeks of TPM treating. A combination treatment of TPM was better than TPM alone(65.9% vs. 40.0%). TPM had a better effect in bipolar disorder type Ⅱ than in bipolar disorder type Ⅰ,mixed bipolar disorder and not specified (81.8% vs. 54.2%, 60.0%, 33.3%). Adverse effects included minor akathisia, tremor, somnolence and gastrointestinal side effects. Conclusion:TPM may be useful in patients with manic disorder,especially in bipolar disorder type Ⅱ.A combination treatment of TPM is recommended.