血小板输注治疗血液病患者79例的效果

Efficiency of platelet transfusion in patients with hematologic diseases

目的 探讨出血性血液病患者血小板输注效果及影响因素 .方法 79例血液病患者 (急性白血病 5 3例 ,再生障碍性贫血 2 6例 ) ,输注单采或多人份混合血小板悬液 ,1h和2 4h后检测外周血小板计数 ,以校正血小板计数增值 (CCI)判定输注效果并讨论其影响因素 .结果 1单采组 CCI显著高于混合组 (1h P<0 .0 5 ,2 4h P<0 .0 1) ;2 87.3%出血症状改善或消失 ;3急白感染组无效输注率为 5 0 .0 % ,非感染组 18.5 % (P<0 .0 1) ;4急性白血病 (AL)组无效输注率15 .1% ,再生障碍性贫血 (AA)组 46 .2 % .结论 血小板输注是治疗因血小板减少导致出血的有效措施 ,感染影响输注效果 。

AIM To investigate the effect of platelet transfusion in patients with hematologic diseases and the influence factors. METHODS The apheresis platelets (AP) and platelet rich plasmas (PRP) were transfused to 79 patients (acute leukemia, 53 cases, aplastic anemia, 26 cases). Peripheral blood platelet counts were made at 1 h, 24 h after platelet transfusion. The effectiveness was assayed by correct count increment (CCI) and the influence factors were analyzed. RESULTS ①The CCI in AP group was much higher than that in PRP group (1 h P <0.05, 24 h P <0.01); ②87.3% bleeding symptoms were improved or disappeared; ③The PTR was 50.0% in infected leukemia patients and 18.5% in non infected leukemia group; ④The PTR was 15.1% in leukemia group and 46.2% in aplastic anemia (AA) group. CONCLUSION Platelet transfusion is an effective procedure to cure bleeding in thrombocytopenia. Infection is another important influence factor. PTR is higher in AA.