脑出血患者血清神经元烯醇化酶动态测定的研究

Dynamic test of serum neuron specific enolase in patients with cerebral hemorrhage.

目的探讨脑出血患者血清神经元烯醇化酶 (NSE)与出血量和临床预后的关系。方法采用酶联免疫吸附法对 42例脑出血患者起病第 1、3、7天血清 NSE水平进行了动态测定。结果脑出血患者血清 NSE浓度在起病第 1、3天显著高于对照组 (P<0 .0 1) ,3天达峰值 ,峰值浓度与出血量及临床预后有显著相关性。结论血清 NSE水平测定对判断脑出血病变的严重度、评估预后有重要参考价值。

Objective To study the relationship between serum neuron specific enolase (NSE) and volume of hemorrhage in patients with cerebral hemorrhage and the relationship between serum NSE and prognosis of the patients.Methods The serum NSE of 42 patients with cerebral hemorrhage was tested with ELISA at 1,3 and 7 days after the hemorrhage happened.Results The serum NSE values at 1 and 3 days after the hemorrhage occurred were higher than that of control group (P<0.01) and peaked at 3 days.The peak value was significantly correlated with volume of cerebral hemorrhage and prognosis.Conclusion The serum NSE test in patients with cerebral hemorrhage is very useful in judging the severity of the disease and the prognosis of the patients.