胰岛素自身抗体与胰岛素抵抗的关系

Insulin Autoantibodies Associated with Insulin Resistance

目的 通过对糖尿病患者血清胰岛素自身抗体 (IAA)的检测 ,了解 IAA与胰岛素抵抗 (IR)产生是否有关联及其与高血压和微血管病变发生之间的内在联系。 方法 采用 EL ISA方法检测 30 9例糖尿病患者血清中 IAA。 结果 糖尿病患者 IAA总检出率为 6 7.31%。IAA阳性病例中 ,伴发血管病变者 (70 .5 4%～ 75 .31% )较无并发症者 (18.5 2 % )显著增高 (P<0 .0 1) ,微血管病变的发生率 (39.48% )与高血压的发生率 (2 9.45 % )差异无显著性 (P>0 .0 5 )。不同性别 IAA检出率 (6 5 .6 4%和 6 9.18% )差异也无显著性 (P>0 .0 5 )。 结论 IAA阳性者微血管病变和高血压的发生机率均较 IAA阴性者明显增高 ,IAA可能是导致 IR重要因素。

Objective To study the correlation among insulin autoantibodies, insulin resistance(IR) and diabetic with microvessel disease and hypertension. Methods The serum insulin autoantibody(IAA) was measured by enzyme linked immunosorbent assay in 309 cases of diabetes mellitus(DM). Results Positive rate of IAA in serum of DM was 67 31%. In cases of IAA positive, the diabetic with blood vessel disease(70 54%~75 31%) increased markedly as compared with patient without this complication(18 52%). There was no difference between the occurence rate of diabetic with microvessel disease(39 48%) and with hypertension(29 45%,P>0 05). No difference of positive rate of IAA was found between men and women(65 64% and 69 18%,P>0 05). Conclusion The incidence rates of microvessel disease and of hypertension are markedly increased in IAA positive diabetics, so IAA may be one of the dangerous factors causing IR.