幽门螺杆菌与慢性荨麻疹的关系

The Relationship between Helicobacter pylori and Chronic Urticaria

目的 探讨幽门螺杆菌 (Hp)与慢性荨麻疹之间的关系。 方法 采用间接酶联免疫吸附法 (EL ISA )检测 30例单用抗组胺药治疗效差的慢性荨麻疹患者和 2 1例健康人 (对照组 )的血清抗 Hp抗体 (Hp- Ig M)。阳性者予克拉霉素、替硝唑、枸橼酸铋钾三联治疗。 结果 抗 Hp- Ig M抗体阳性率在慢性荨麻疹为 6 0 .0 % ,对照组为 2 8.6 % ,两组差异有显著性 (P<0 .0 5 )。经抗 Hp三联治疗后 8周 ,94.4%的患者荨麻疹症状完全缓解 ,抗 Hp- Ig M抗体转阴。 结论 Hp感染可能是部分慢性荨麻疹的诱因之一。

Objective To investigate the relationship between helicobacter pylori(Hp) and chronic urticaria(CU). Methods By enzyme linked immunosorbent assay(ELISA), serum specific IgM antibodies(Hp IgM) in 30 cases of CU and 21 cases of healthy controls were detected. The patients with positive Hp IgM were treated by clarithromycin, tinidazole and bismuth potassium citrate(triplicated therapy). Results The positive rate for Hp IgM antibody were 60 0% in CU patients and 28 6% in control. The difference was significant(P<0 05). Conclusion Helicobacter pylori infection may be one of induced factors in some patients with chronic urticaria.