抗前列腺增生药SL-89.0519-08的合成

Synthesis of SL-89.0519-08

目的 :研究治疗前列腺增生的 α1 -受体拮抗剂 SL-89.0 5 19-0 8的合成路线。方法 :以 5 -氯 -2 -甲氧基苯胺为原料 ,经环合、烃化、脱保护基和亲核取代等步骤 ,合成了目标化合物 ,同时对原料的合成工艺进行了摸索。结果 :合成的目标化合物经 IR,1 HMNR,EI-MS和 HRMS得以确证。结论 :该合成工艺和路线适宜工业化生产。

AIM The purpose is to make a research of synthetic scheme of adrenergic antagonist SL 89.0519 08 for the treatment of benign prostatic hyperplasia. METHODS Using 5 chloro 2 methoxyaniline, the target compound was synthesized after steps of cyclization, alkylation, deprotective group and nucleophilic substitution, meanwhile the synthetic method was studied. RESULTS The compound was confirmed by IR, 1HNMR,EI MS and HRMS. CONCLUSION This synthesis is suitable for industrial manufacture.