黄花败酱的化学成分研究

Studies on the Constituents of Patrinia scabiosaefolia Fisch

目的 :对黄花败酱的化学成分进行研究。方法 :采用乙醇提取、溶剂萃取、硅胶柱层析、重结晶等从败酱科植物黄花败酱的全草中提取分离活性成分 ,通过波谱解析及化学方法进行结构鉴定。结果 :自黄花败酱醇提物中分得 8个化合物。结论 :除文献报道过的齐墩果酸 (oleanolic acid)、东莨菪素 (scopoletin)、β-谷甾醇 (β-sitosterol )和β-胡萝卜甙 (daucostarine)外 ,还首次从黄花败酱中分到 2α-羟基齐墩果酸 (2α-hydroxyoleanolicacid)、2α-羟基乌苏酸 (2α-hydroxyursolic acid)、齐墩果酸 -3 -O-β-D-吡喃木糖苷 (oleanolic acid-3 -O-β-D -xylopy-ranoside )和 3 ,4-二羟基苯甲酸 (3 ,4-dihydroxybenzoic acid )

AIM Bioactive constituents were expected to obtain from \%Patrinia scabiosaefolia\% Fisch. METHODS They were extracted with ethanol, distributed by different solvents, isolated and purified via column chromatography on silica gel. Structures were elucidated based on spectral evidences and chemical studies. RESULTS A chemical study on the whole plant of \%Patrinia scabiosaefolia\% was carried out, and eight compounds have been isolated and identified as oleanolic acid, 2α hydroxyoleanolic acid, 2α hydroxyursolic acid, oleanolic acid 3 O β D xylopyranoside, scopoletin, 3, 4 dihydroxybenzoic acid, β sitosterol, daucosterol. CONCLUSION 2α Hydroxyoleanolic acid, 2α hydroxyursolic acid, oleanolic acid 3 O β D xylopyranoside and 3, 4 dihydroxybenzoic acid were isolated from Patrinia scabiosaefolia for the first time.