少精、无精症患者染色体及FSH、LH、PRL、T水平分析

The chromosome and hormone analysis in patients with oligo-spermia and azoospermia

目的:检测少精、无精症患者染色体畸变情况及血清激素水平。方法:采用常规染色及显带分析技术对67例患者外周血淋巴细胞染色体定性分析,并根据结果将67例患者分为染色体畸变组(A组,n=16)、无染色体畸变组(B组,n=51),并设健康对照组C组,n=26),采用放射免疫(RIA)法对各组血清FSH、LH、PRL、T激素进行测定。结果:染色体分析显示患者的总畸变率为23．88%(l6/67),其中常染色体畸变率:4．48%(3/67),性染色体畸变率;19．40%(13/67)。激素测定显示:A组4种激素、B组FSH、LH水平与对照组相比差异均有显著性(P＜0．05)。结论:少精、无精症与性染色体畸变及多种血清激素异常密切相关,与常染色体畸变也有一定联系。

Aim: To detect the chromosome aberration and serum hormone in cases of oligosperrnia or azoospermia. Methods: The chromosome of 67 cases of oligosperrnia or azoospermia was analyzed by using karyotype anlysis and all the cases were allocated into the aberrant chromosome group(group A, n = 13), the non-aberrant chromosome group (group B, n = 51), and the normal control group (group C, n = 26); the levels of serum FSH, LH. PRL and T were detected by using radioimmunoassay . Results: The total aberrantion rate of the chromosome was 23. 88%(19. 40% for the abnormal sex chromosome and 4. 48% for the autosome). The levels of serum FSH, LH, PRL, and T in group A, and the levels of FSH and LH in group B had significant difference compared to group C (all P<0. 05). Conclusion: The aberrant sex chromosome, autosome, and abnormal hormone are related to the incidence of oligosperrnia and azoospermia.