应激诱发复吸行为的生物学机制研究进展

Stress-induced relapse and its potential neurobiological mechanism

复吸是药物依赖的主要特征 ,也是治疗的首要问题。应激可以诱发复吸。应激诱发复吸的神经生物学机制不同于启动药物诱发复吸的机制。启动药物诱发复吸涉及中脑边缘多巴胺通路的激活 ;而应激诱发复吸主要涉及脑去甲肾上腺素和促肾上腺皮质激素释放因子 ,终纹床核是两者相互作用的关键部位。去甲肾上腺素外侧被盖核和终纹床核是应激诱发复吸的重要脑区。不同应激源可能通过相关机制诱发复吸。

Relapse is a characteristic feature of drug dependence, and remains as a major concern in treating drug addiction. Stressor induces relapse. The neurobiological mechanism of stress induced relapse is different from that of priming drug induced relapse. Norepinephrine (NE) and corticotropin releasing factor (CRF) are important during stress induced relapse, but a minimal basal dopamine and corticosterone are necessary for the manifestation of stress induced reinstatement. The lateral tegmental noradrenergic nuclei and the bed nucleus of the stria terminalis (BNST) are the important brain areas of stress induced relapse. In addition, evidence shows that CRF and NE may interact at the level of BNST in stress induced relapse.