诺维本与顺铂治疗非小细胞肺癌

The treatmet of NSCLC by Navelbine and cisplation

目的 观察诺维本 (navrelbine,NVB)加顺铂治疗非小细胞肺癌 (non small cell lung cancer,NSCL C)的疗效。方法 治疗 NSCL C40例。病理类型鳞癌 36例 ,腺癌 4例。 期 4例 , a期 16例 , b期和 期各 10例。 2 0例初治 ,2 0例复治。结果 :CR4例 ,PR15例 ,NC2 0例 ,PD1例。总有效率 47.5 %。其中初治有效率为 6 0 % ,复治有效率为 35 % ,NVB的主要毒副反应为骨髓抑制 ,WBC下降占 10 0 % ,其中 、 度为 80 .5 % ,局部静脉炎发生率为 35 %。结论 经过简化的 NVB+PDD治疗 NSCL C有效率较高 ,毒性相对较低 ,尤其对分期较早的病人 ,效果更好。

Objective To evaluate the effect by'standard/chemotherapy with naelbine(NVB)plus cisplatin(PDD) in the treatment of non small cell lung cancer(NSCLC).Methods There were 40 NSCLC patients in this study.38 were male and 2 female.The median age of the patients was 52 years old.Squamous carcinoma was the most common type of malignancy(36 cases).Sixteen patients were in the stage Ⅲa and 20 patients in stage Ⅲb Ⅳ.Twenty patients had no prior chemotherapy and 20 received previous chemotherapy.Results Complete response was observed in 4 patients and partial response in 15 patients.The overall response rate was 47.5%.The response rate of the primary chemotherapy was 60%.The secondary chemotherapy was 35%.The main toxity of NVB was neutropenia which was seen in all treated cases(80.5% in Grade Ⅱ and Ⅲ).The local venous toxity was observed in 35% of the patients.Conclusion The so called standard chemotherapy with NVB plus PDD in the treatment of NSCL may obtain a higher response rate and lower toxity.It is effective especially for the patients of in an earlier stage.