氧自由基在小儿病毒性心肌炎发病中的作用和硫酸锌治疗作用研究

ffect of zinc sulfate on cardiac muscle injured by oxygen free radical

为探讨氧自由基 (OFR)在病毒性心肌炎 (VMC)发病中的作用及硫酸锌 (Zn SO4 )对 OFR损伤心肌的治疗作用 ,进行了相关临床研究和动物实验。结果显示 ,6 1例 VMC患儿血中过氧化物歧化酶 (SOD)降低 ;丙二醛(MDA)及左室射血分数 (L VEF)升高 ;SOD与 CK- MB呈负相关 ,与 L VEF呈正相关 ;MDA与 CK- MB呈正相关 ,与 L VEF呈负相关。Zn SO4 与维生素 C均可使心肌细胞存活力升高 ,L DH浓度降低 ,SOD活力升高 ,MDA降低 ;Na- K ATP酶和 Ca ATP酶活力升高。大剂量 Zn SO4 治疗 VMC的疗效好于大剂量维生素 C和小剂量 Zn SO4 。

The action of oxygen free radical(ORF)to viral myocarditis(VMC)and the treatment effect of zinc sulfate (ZnSO 4) to the cardiac muscle injured by OFR were reported.The superoxide dismutase(SOD)and left ventricular ejection fraction(LVEF)were decreased and malonaldehye (MDA) was deceased in 60 patients with VMC.The decreased of SOD was positive related to EF and negative related to CK MB.ZnSO 4 increased the viability of H 2O 2 injured cardiomyocytes,decrease LDH and MDA content,decrease SOD activity in culture media and increase Na + K + ATPase and Ca 2+ ATPase activity in the cardiomyocytes.Large dose ZnSO 4(60μmol/L) is more effective than small dose ZnSO 4(15μmol/L) and Vitamin C (50mg/L).