黑素细胞与白癜风

Melanocytes and Vitiligo

白癜风是原发性的局限或泛发的皮肤色素脱失性疾病,人群中的发病率为1％-2％,病理表现为局部黑素细胞缺失。临床上对于常规治疗反应不佳的顽固型病人可采用手术移植。白癜风病人常存在的免疫缺陷和黑素细胞的功能异常一定程度上影响了自体表皮移植和自体黑素细胞移植的疗效。对正常人黑素细胞表面抗原表达及对同种异体抗原性的研究提示,黑素细胞异体移植治疗白癜风具有可行性。同时黑素细胞体外纯培养方法的改进加速了这一方法的研究。

Vitiligo is an idiopathic disease, clinically characterized by the presence of amelanodermic macules due to loss of melanocytes. Its incidence in the general population ranges from 1% to 2%. The surgical transplantation is always applied to the patients with refractory vitiligo. The success rate of autologous epidermal transplantation and cultured melanocytes transplantation is limited by the defect of melanocytes of patients with vitiligo. The recent experiment reveal that treat the refractory vitiligo by transplantation of allogeneic cultured melanocytes is viable. The development of the method of melanocytes culture in vitro accelerates this process.