对肝硬化顽固性腹水病人的治疗作用

Therapeutical Effect of Lizhuchangle for CirrhosisPatients with Refractory Ascites

目的 探讨丽珠肠乐对肝硬化顽固性腹水并发菌群失调的治疗作用。方法 选择住院治疗肝硬化顽固性腹水病人67例,在基础支持疗法和护肝、利尿、抗感染治疗基础上,按入院顺序分为丽珠肠乐治疗组(35例)和乳果糖组(32例),观察治疗前、后病人的腹水、生化、血氨、血浆内毒素等的变化。结果 丽珠肠乐组和乳果糖组67例病人治疗后病情有不同程度的缓解,腹水消失或减少,生化指标改善,血氨和血浆内毒素水平明显降低,与治疗前比较,分别有极其显著的差异(P<0.01)。两组治疗后比较,丽珠肠乐组降低血氨和内毒素的作用明显优于乳果糖组,分别有极其显著的差异(P<0.01)。6例原发性腹膜炎病人也取得较好疗效。结论 丽珠肠乐对肝硬化顽固性腹水病人合并胃肠功能紊乱和菌群失调的治疗有明显的辅助治疗作用。可有效纠正肝硬化顽固性腹水病人的球茵/杆菌比例失调,通畅大便和排气,减轻病人腹胀症状,降低血氨和血浆内毒素,防止发生其它并发症。

Objective To investigate therapeutical effect of Lizhuchangle for cirrhosis patients with refractory ascites and dysbacteriosis. Method 67 cirrhosis patients with refractory ascites were studied, who were divided randomly into Lizhuchangle group (n=35) and lactulose group (n=32),routine therapy and liver protection.diuresis and infection resistance were continued. Ascites. biochemistry index ,biood ammonia, plasma endotoxin etc. were measured before and after the treatment. Result The condition of 67 patients in the treatment had relived in different degree ,ascites reduced or disappeared,biochemistry index improved, blood ammonia and plasma endotoxin decreased significantly,all those had significant difference after treatment ( P<0.01). Compared with the two teams .the effect of Lizhuchangle decreased blood ammonia and plasima endotoxin more than lactulose did, which had significant difference ( P<0.01). 6 patients with primary pentonitis also had better result. Conclusion Lizhuchangle had a good helpful therapeutical effect to the cirrhosis patients with refractory ascites and gastrointestinal function disorganized and dysbacteriosis, it can adjust proportion maladjustment of coccus/bacillus in cirrhosis patients with refractory ascties, defecate and exhaust smooth, relief abdomen swell, reduce blood ammonia and plasma endotoxin, avoid relevant combined disease.