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应激、糖皮质激素和海马老化 被引量:15

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摘要 应激可导致丘脑-垂体-肾上腺(HPA)轴亢进,过量的糖皮质激素(CCS)使海马功能紊乱.加速海马老化。衰老的级联损伤学说:老化的海马神经元的糖皮质类固醇激素受体(GR和MR)减少,加重HPA轴亢进程度,超生理剂量GCS通过复杂分子机制加速脑衰老。药物干预措施的研究:调节海马GR和MR,下调亢进的GCS,延缓脑老化成为可能。
作者 赵刚 蔡定芳
出处 《国外医学(老年医学分册)》 2002年第3期125-128,共4页 Foreign Medical Sciences(Geriatrics)
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