小儿急性毒鼠强中毒的血液灌流治疗

Hemoperfusion therapy in children with acute tetramethenedisulphonetetramine(TETS) intoxication

目的 探讨子母活性炭血液灌流对毒鼠强中毒的治疗价值。 方法 采用BP 2 1血液灌流装置对 14例毒鼠强中毒患儿进行床边血液灌流治疗 ,测定患儿灌流前血、尿液、灌流后即刻及 2 4h血、72h的血、尿毒鼠强浓度 ;并与既往常规治疗的 11例患儿疗效进行比较。 结果 血液灌流后毒鼠强浓度明显下降 (P <0 0 1) ;血液灌流组与常规非血液灌流组比较 ,相同时期内血液、尿液毒鼠强浓度有明显下降 ,血浓度下降值分别为 ( 74 9± 2 1 8) μg/ml和 ( 11 5± 5 9) μg/ml,尿毒鼠强浓度下降值分别为( 79 4± 14 9) μg/ml和 ( 16 4 ± 7 8) μg/ml,两者均有显著差异P <0 0 1。 结论 炭肾血液灌流对毒鼠强有很好的吸附作用 ,吸附前后的血药浓度明显降低 ,炭肾血液灌流治疗毒鼠强中毒比常规治疗更有效。

Objective To analyse the clinical efficacy of hemoperfusion with active carbon in children with acute TETS intoxication.Methods We used BP-21 hemoperfusion apparatus to treat 14 cases of children with acute TETS intoxication.The concentration of TETS was measured from blood and urine before and after treatment.The clinical results were compared with conventional therapy (non-hemoperfusion) in 11 cases.Results The clinical effect of hemoperfusion therapy was satisfactory.The blood and urine TETS concentration of the hemoperfusion patients was obviously dropped than that without hemoperfusion 〔blood:(74\^9±21\^8)μg/ml vs (11\^5±5\^9)μg/ml;urine:(79\^4±14\^9)μg/ml vs (16\^4±7\^8)μg/ml,both P<0\^01〕.Conclusion TETS can be absorbed fully by active carbon through hemoperfusion. Hemoperfusion therapy is better than conventional therapy in patients with TETS intoxication.