石杉碱甲治疗轻中型颅脑外伤记忆及认知障碍的临床研究

A clinical study of huperzine A on mild and moderate traumatic brain injury in memory and cognitive impairment

目的 :观察石杉碱甲对轻中型颅脑外伤患者记忆、认知功能障碍的治疗作用及对体感诱发电位的影响 ,从脑电生理的角度探讨其作用机制。方法 :将 6 0例轻中型颅脑外伤患者随机分为常规治疗组和石杉碱甲治疗组 ,在治疗前及治疗 1个月和 3个月后分别采用记忆商 (MQ)和简明智力状态检查 (MMSE)评估记忆和认知功能并检测上肢体感诱发电位 (SEP)。结果 :石杉碱甲治疗组和常规治疗组治疗后 ,记忆、认知功能均有明显改善。在治疗 1个月及 3个月后 ,治疗组记忆功能改善较常规组显著 (P <0 .0 5 ) ,体感诱发电位N2 0 潜伏期和N13 -N2 0 峰间潜伏期明显缩短。两组MMSE评定结果无统计学差异。结论

Objective:To observe the treatment effect of huperzine A on mild and moderate traumatic brain injury in memory and cognitive impairment and the effect on somatosensory evoked potentials. To explore the mechanism of huperzine A from brain electrophysiology. Method: 60 patients with mild and moderate traumatic brain injury were divided randomly into traditional treatment group and huperzine A treatment group. The functions of memory and cognition were assessed with memory quotient (MQ) and mini mental status examination (MMSE) respectively before and after 1 month and 3 month of treatment. The upper limb somatosensory evoked potentials were examined at the same time. Result: The functions of memory and cognition in both groups were improved distinctly after treatment. The memory of huperzine A treatment group improved more dramatically than that of traditional treatment group after 1 and 3 month of treatment. The peak latency of N 20 and interpeak latency of N 13 -N 20 were shortened markedly in huperzine A treatment group. There was no statistical difference in MMSE values between the two groups. Conclusion: Huperzine A can improve the memory function and central nerve conduction in patients with mild and moderate traumatic brain injury.