摘要
目的 :观察葛根素对豚鼠单个心室肌细胞钾离子通道的影响。方法 :采用内面向外膜片钳单通道记录技术。结果 :葛根素 2 0 μmol/L ,4 0 μmol/L ,80 μmol/L对单个心肌细胞钾离子通道的开放概率 (P0 )有抑制作用 ,在 80μmol/L时 ,P0 值从 0 .86 7± 0 .13降至 0 .0 19± 0 .0 1,与用药前比较有显著差异 (n =5 ,P <0 .0 1)。结论
Aim and Methods: To observe the effects of Puerarin on K + channel of isolated ventricular myocyte in guinea pig. Methods: Using inside out configuration of patch clamp single channel recording technique.Results: Puerarin 20 μmol/L, 40 μmol/L, 80 μmol/L could inhibit the open close rate of K + channel of isolated ventricular myocyte in guinea pig. At 80μmol/L, Po was decreased from 0.867+0.13 to 0.019+0.01 ( n=5, P <0.05). Conclusion: Puerarin can inhibit K + channel of isolated ventricular myocyte in guinea pig. It may be the mechanism of Puerarin against arrhythmias in molecular level.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2002年第2期155-158,共4页
Chinese Journal of Applied Physiology
基金
四川省科委资助项目
